This article describes a facile synthesis of 2-substituted-5-(ketoaryl)thiazoles, which are important intermediates for the synthesis of biologically active compounds. A variety of 2-substituted thiazole anions were added to aryl nitriles to provide the desired ketones after aqueous hydrolysis.
Marcantonio, Karen M.,Frey, Lisa F.,Murry, Jerry A.,Chen, Cheng-Yi
p. 8845 - 8848
(2007/10/03)
Spirodioxolane Intermediates in the Reaction of 2-(Trimethylsilyl)thiazole with Aldehydes. Support for the 2-Ylide Mechanism
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Dondoni, Alessandro,Douglas, Alan W.,Shinkai, Ichiro
p. 3196 - 3200
(2007/10/02)
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