137466-13-8Relevant articles and documents
Nuclear Spin-Spin Coupling via Nonbonded Interactions. 7. Effects of Molecular Structure on N-F Coupling
Mallory, Frank B.,Luzik, Eddie D.,Mallory, Clelia W.,Carroll, Patrick J.
, p. 366 - 370 (1992)
To test wether the recently discovered phenomenon of through-space nuclear spin-spin coupling between intramolecularly crowded 15N and 19F nuclei shows the same sort of striking dependence on molecular structure as the long-known phenomenon of through-space nuclear spin-spin coupling between pairs of intramolecularly crowded 19F nuclei, several 15N-enriched oximes and some simple derivatives thereof were synthesized and their JNF values were determined by 19F NMR spectroscopy.The experimental JNF values ranged from 8.6 to 43.5 Hz.The molecular structures of these compounds were determined by single-crystal X-ray diffraction.The observed dependence of the 15N-19F coupling constants on molecular structure was qualitatively consistent with the predictions of the lone-pair orbital overlap theory that was developed earlier to account for through-space coupling involving fluorine nuclei.
3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE
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Paragraph 1435-1438, (2015/04/15)
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.
