- Superacid-promoted reactions of N-acyliminium ions: An effective route to substituted 3-oxo-1,2,3,4-tetrahydroisoquinolines and related products
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Intramolecular cyclizations involving N-acyliminium ions are shown to give products in good yields from reactions with CF3SO3H (triflic acid). The resulting 3-oxo-1,2,3,4-tetrahydroisoquinolines have been converted in high yields to 1,2-diaryl-1,2,3,4-tetrahydroisoquinolines, which have been recently shown to be selective estrogen receptor modulators. In a reaction using a chiral N-acyliminium ion, cyclization is found to occur in moderately high diastereoselectivity. Several examples of intermolecular triflic acid-promoted reactions are also reported. Georg Thieme Verlag Stuttgart.
- Zhang, Yiliang,Kindelin, Patrick J.,DeSchepper, Daniel J.,Zheng, Chong,Klumpp, Douglas A.
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p. 1775 - 1780
(2008/01/27)
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- NOUVELLE VOIE DE SYNTHESE DES 1,4-DIHYDROISOQUINOLEIN-3(2H)-ONES
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The 1,3-dipolar cycloaddition of arylazides with 1,2-dihydro-isoquinoline derivatives leads to new triazolinic adducts.The thermolysis of these latters followed to a hydrolysis conducts to 1,4-dihydroisoquinolin-3(2H)-ones.The structure of the adducts and
- Kitane, Said,Chraibi, Leila,Soufiaoui, Mohamed
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p. 8935 - 8946
(2007/10/02)
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- LITHIATION OF 1-ARYL-1,4-DIHYDRO-3(2H)-ISOQUINOLINONES AND THEIR N-METHYL DERIVATIVES
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N-methyl analogues of several 1,4-dihydro-3(2H)-isoquinolinone derivatives have been prepared via methylation with dimethyl sulphate; in some experiments the O-methyl lactim ethers have also been isolated.The incorporation of lithium into the N-methyl com
- Hazai, Laszlo,Deak, Gyula,Szoelloesy, Aron,Toth, Gabor,Bitter, Istvan
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p. 263 - 270
(2007/10/02)
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