- A new class of bioactivable self-immolative N,O-ligands
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A hexadentate ligand built on an amine-bis(phenol) skeleton with an aminal, self-immolative moiety is presented. Synthesis of the ligand is convenient and relatively high yielded. Moreover, it enables synthesis of many derivatives, both in the amino-phenol and aminal fragment (various heterocycles). Once the final hexadentate ligand is synthesized via the Katritzky reaction, it becomes prone to hydrolysis. Bioactivation by β-galactosidase cleaves the glycosylic bond and a spontaneous collapse of the aminal fragment occurs, thus leading to a pentadentate chelate. This bioactivation has been shown for pyrazole, 1,2,4-triazole and benzotriazole derivatives.
- Ku?nik, Nikodem,Chrobaczyński, Arkadiusz,Mika, Ma?gorzata,Miler, Patrycja,Komor, Roman,Kubicki, MacIej
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p. 184 - 192
(2012/07/28)
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