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CAS

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137987-85-0

1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone is a chemical compound with the molecular formula C16H16O4. It is a yellow crystalline powder with a molecular weight of 272.29 g/mol. 1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone is a derivative of phenylpropanoid and features two hydroxyl groups attached to the phenyl ring. Its high reactivity and versatile chemical properties make it a valuable compound for use in the synthesis of pharmaceuticals and organic compounds.

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  • 137987-85-0 Structure

  • Basic information

    1. Product Name: 1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone
    2. Synonyms: 1-(2,4-Dihydroxyphenyl)-2-(3-methylphenoxy)ethanone; ethanone, 1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)-
    3. CAS NO:137987-85-0
    4. Molecular Formula: C15H14O4
    5. Molecular Weight: 258.2693
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 137987-85-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 486.5°C at 760 mmHg
    3. Flash Point: 186.1°C
    4. Appearance: N/A
    5. Density: 1.275g/cm3
    6. Vapor Pressure: 4.33E-10mmHg at 25°C
    7. Refractive Index: 1.619
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone(137987-85-0)
    12. EPA Substance Registry System: 1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone(137987-85-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 137987-85-0(Hazardous Substances Data)

137987-85-0 Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique molecular structure and reactivity contribute to the development of new medications with potential therapeutic benefits.
Used in Fragrance and Flavor Production:
In the fragrance and flavor industry, 1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone is used as a key component in the creation of various scents and tastes. Its chemical properties allow for the development of novel and distinct fragrances and flavors that can be used in a wide range of consumer products.
Used in Chemical Manufacturing Processes:
1-(2,4-dihydroxyphenyl)-2-(3-methylphenoxy)ethanone also serves as an intermediate in chemical manufacturing processes. Its versatility and reactivity make it a valuable compound for the production of various organic compounds and materials, contributing to the advancement of research and development in multiple industrial and scientific fields.

Check Digit Verification of cas no

The CAS Registry Mumber 137987-85-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,9,8 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 137987-85:
(8*1)+(7*3)+(6*7)+(5*9)+(4*8)+(3*7)+(2*8)+(1*5)=190
190 % 10 = 0
So 137987-85-0 is a valid CAS Registry Number.

137987-85-0Relevant articles and documents

ANTI-VIRULENCE COMPOSITIONS AND METHODS

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Paragraph 00140, (2014/05/07)

A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical composition effective to inhibit the synthesis of one or more virulence factors by the bacterium, the pharmaceutical composition including an AgrA antagonist.

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Yu, Guanping,Kuo, David,Shoham, Menachem,Viswanathan, Rajesh

, p. 85 - 91 (2014/03/21)

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.

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