Catalytic enantioselective alkene aminohalogenation/cyclization involving atom transfer
Problem solved: The title reaction was used for the synthesis of chiral 2-bromo, chloro, and iodomethyl indolines and 2-iodomethyl pyrrolidines (see scheme). Stereocenter formation is believed to occur by enantioselective cis aminocupration and C-X bond formation is believed to occur by atom transfer. The ultility of the products as versatile synthetic intermediates was demonstrated, as was a radical cascade cyclization sequence. Copyright
Bovino, Michael T.,Chemler, Sherry R.
p. 3923 - 3927
(2012/05/20)
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