138165-79-4

Basic information

• Product Name: (S)-BOC-2-AMINO-3-(3-INDOLYL)-PROPIONITRILE
• Synonyms: BOC-(S)-2-AMINO-3-(3-INDOLYL)-PROPIONITRILE;(S)-BOC-2-AMINO-3-(3-INDOLYL)-PROPIONITRILE;(S)-Boc-2-amino-3-(1H-indol-3-yl)-propionitrile
• CAS NO: 138165-79-4
• Molecular Formula: C16H19N3O2
• Molecular Weight: 285.34
• Mol File: 138165-79-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Store at 0-5°C
• CAS DataBase Reference: (S)-BOC-2-AMINO-3-(3-INDOLYL)-PROPIONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-BOC-2-AMINO-3-(3-INDOLYL)-PROPIONITRILE(138165-79-4)
• EPA Substance Registry System: (S)-BOC-2-AMINO-3-(3-INDOLYL)-PROPIONITRILE(138165-79-4)

Safety Data

• Hazardous Substances Data: 138165-79-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 62549-92-2 Boc-Trp-NH₂ 
• 1314911-34-6 chlorosulfonyl methylcarbamate 

Relevant articles and documents

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.

Endothelin receptor antagonists

The present invention provides novel compounds represented by the general formula I: STR1 wherein R 1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a cycloalkyl, an aryl an aryl-cycloalkyl, lower alkoxy, an aryloxy, or a heteroaryl;R 2 is hydrogen, a straight or branched lower alkyl, a cycloalkyl, or a cycloalkyl-lower alkyl;R 3 and R 3 '' are each the same or different and each is hydrogen atom, a straight or branched lower alkyl, a cycloalkyl, an aryl-lower alkyl, an aryl, or a heteroaryl; orR 3 and R 3 '' together form a ring structure;R 3 "" is hydrogen, lower alkyl or an aryl; orR 2 and R 3 "" together form a lower alkylene group --(CH 2) n -- wherein n is an integer of 1, 2 or 3; orR 2 and R 3 "" together form a group represented by the formula: --(CH 2) p --Ar-- or --Ar--(CH 2) p --, respectively, wherein p is zero or an integer of 1 or 2, and Ar is an arylene or heteroarylene;C( X) is C( O), C( S), C( NH), C( N-lower alkyl); C NH--OH, or CH 2 ;Y is a direct bond, --NH--, a lower alkyl-N, an oxygen atom, or methylene; orC( X) is CHOH and Y is a direct bond or methylene;R 4 is --(CH 2) s --Ar'' wherein s is zero or an integer of 1, 2 or 3; and Ar'' is an aryl, or a heteroaryl; andR 5 is carboxy, substituted or unsubstituted carboxamide, PO(OH) 2, tetrazole, CH 2 OH, CN, or hydrogen;and salts thereof.

3,3,3-TRIFLUORO-2-MERCAPTOMETHYL-N-TETRAZOLYL SUBSTITUTED PROPANAMIDES AND METHOD OF USING SAME

Compounds of the formula STR1 wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.