138261-30-0Relevant articles and documents
Synthesis and evaluation of etoposide and podophyllotoxin analogs against topoisomerase IIα and HCT-116 cells
Barton, Christopher E.,Bradley, Amber M.,Deweese, Joseph E.,Kumar, Priyanka,Mercer, Susan L.,Murphy, Matthew B.
, (2020)
Etoposide is a widely-used anticancer agent that targets human type II topoisomerases. Evidence suggests that metabolism of etoposide in myeloid progenitor cells is associated with translocations involved in leukemia development. Previous studies suggest
Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins
Hu,Wang,Liu,Cheng,Lee
, p. 866 - 871 (2007/10/02)
The 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-lin