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138277-78-8

ALNESPIRONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 138277-78-8 Structure

  • Basic information

    1. Product Name: ALNESPIRONE
    2. Synonyms: 8-(4-((5-methoxychroman-3-yl)(propyl)amino)butyl)-8-azaspiro[4.5]decane-7,9-dione
    3. CAS NO:138277-78-8
    4. Molecular Formula: C26H38N2O4
    5. Molecular Weight: 442.596
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 138277-78-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: ALNESPIRONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: ALNESPIRONE(138277-78-8)
    11. EPA Substance Registry System: ALNESPIRONE(138277-78-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 138277-78-8(Hazardous Substances Data)

138277-78-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 138277-78-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,2,7 and 7 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 138277-78:
(8*1)+(7*3)+(6*8)+(5*2)+(4*7)+(3*7)+(2*7)+(1*8)=158
158 % 10 = 8
So 138277-78-8 is a valid CAS Registry Number.

138277-78-8Downstream Products

138277-78-8Related news

ArticlesA Comparison of the Oxytocin and Vasopressin Responses to the 5-HT1A Agonist and Potential Anxiolytic Drug ALNESPIRONE (cas 138277-78-8) (S-20499)08/24/2019

VAN DE KAR, L. D., A. D. LEVY, Q. LI AND M. S. BROWNFIELD. A comparison of the oxytocin and vasopressin responses to the 5-HT1A agonist and potential anxiolytic drug alnespirone (S-20499). PHARMACOL BIOCHEM BEHAV 60(3) 677–683, 1998.—The effect of the serotonin1A (5-HT1A) agonist alnespirone (...detailed

Similar pharmacological properties of 8-OH-DPAT and ALNESPIRONE (cas 138277-78-8) (S 20499) at dopamine receptors: comparison with buspirone08/23/2019

Alnespirone (S 20499) has previously been described as a potential anxiolytic drug that acts by stimulation of 5-HT1A receptors. Some data suggest that alnespirone might also be a weak dopamine D2 receptor agonist: it displays moderate affinity for dopamine D2 receptors in vitro and it inhibits ...detailed

Is the potent 5-HT1A receptor agonist, ALNESPIRONE (cas 138277-78-8) (S-20499), affecting dopaminergic systems in the rat brain?08/22/2019

The effects of the new methoxy-chroman 5-HT1A receptor agonist, alnespirone (S-20499), on the dopamine systems in the rat brain were assessed in vivo by means of electrophysiological and neurochemical techniques. Cumulative doses of alnespirone (0.032–4.1 mg kg−1, i.v.) did not modify the spont...detailed

Short communicationAntidepressant-like effects of ALNESPIRONE (cas 138277-78-8) (S 20499) in the learned helplessness test in rats08/19/2019

The effects of the new chroman derivative, alnespirone (S 20499), which is a selective 5-HT1A receptor agonist, were investigated in an animal model of depression, the learned helplessness test. Rats previously submitted to a session of 60 inescapable electric foot shocks (learned helpless contr...detailed

In vivo comparison of two 5-HT1A receptors agonists ALNESPIRONE (cas 138277-78-8) (S-20499) and buspirone on locus coeruleus neuronal activity08/18/2019

The aim of the present study was to compare, in chloral-hydrate anaesthetized rats, the α2-adrenergic properties of the selective 5-HT1A receptor agonist, alnespirone (S-20499), with those of buspirone, a 5-HT1A receptor agonist exhibiting potent α2-adrenoceptor antagonist properties via its p...detailed

138277-78-8Relevant articles and documents

3,4-Dihydro-3-amino-2H-1-benzopyran Derivatives as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents. 1. Synthesis and Structure-Activity Relationship Studies

Podona, Tchao,Guardiola-Lemaitre, Beatrice,Caignard, Daniel-Henri,Adam, Gerard,Pfeiffer, Bruno,et al.

, p. 1779 - 1793 (1994)

A series of 3,4-dihydro-3-amino-2H-1-benzopyran derivatives were prepared in order to determine the necessary structural requirements for good affinity for 5-HT1A receptors and high selectivity versus other receptors.Modifications of the extrac

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