- Method for generating beta-amino ketone compounds through iodine catalysis
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The invention discloses a method for generating beta-amino ketone compounds by catalyzing 4-hydroxy-2-butanone to react with aromatic amine through iodine. The method comprises the following steps: taking 4-hydroxy-2-butanone and different aromatic amines as reaction substrates, taking iodine as a catalyst, and dimethyl sulfoxide or N,N-dimethyl formamide as a solvent, and reacting at room temperature in a nitrogen atmosphere to obtain the beta-amino ketone compounds, wherein other byproducts are undetected. By adopting the preparation method disclosed by the invention, the beta-amino ketone compounds can be generated by catalyzing 4-hydroxy-2-butanoe to react with aromatic amine through the iodine at room temperature for the first time.
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Paragraph 0051-0052
(2019/02/26)
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- Method for catalyzing N-alkylation reaction by TEMPO and TBN
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The invention discloses a method for catalyzing N-alkylation reaction of aniline and 4-hydroxy-2-butanone by TEMPO and TBN. 4-hydroxy-2-butanone and different anilines are used as the reaction substrate, TEMPO (2,2,6,6-tetramethylpiperidine oxide) is used as catalyst, TBN (tert-butyl nitrite) is used as cocatalyst, dimethyl sulfoxide or N,N-dimethylformamide or toluene is used as solvent, N-alkylation product is obtained in nitrogen atmosphere at room temperature, no other by-products are detected. The preparation method of the invention uses TEMPO and TBN to catalyze aniline compounds and 4-hydroxy-2-butanone to perform N-alkylation reaction.
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Paragraph 0060; 0061
(2019/11/20)
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- Iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to form β-aminoketones and Benzo[h]quinolones
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An iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to yield β-aminoketones and benzo[h]quinolones had been developed. Noble metallic catalysts, oxidants, α β-unsaturated ketone intermediates and aza-Michael addition were not involved in this coupling reaction which made it unique when compared to other reactions reported in literature. Inexpensive iodine catalyst, easy accessible raw materials, mild reaction conditions, good functional group tolerance and excellent selectivity made this coupling reaction be a practical method. This reaction can also be scaled up.
- Miao, Changqing,Jiang, Liya,Ren, Lanhui,Xue, Qingxia,Yan, Fang,Shi, Weiwei,Li, Xinjian,Sheng, Jiwen,Kai, Shuangshuang
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p. 2215 - 2228
(2019/02/27)
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- Palladium-catalyzed aerobic oxidative coupling of allylic alcohols with anilines in the synthesis of nitrogen heterocycles
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We report herein an unprecedented and expedient Pd-catalyzed oxidative coupling of allyl alcohols with anilines to afford β-amino ketones which are converted into substituted quinolines in a one-pot fashion. The exclusive preference for N-alkylation over N-allylation makes this approach unique when compared to those reported in literature. Detailed mechanistic investigations reveal that the conjugate addition pathway was the predominant one over the allylic amination pathway. The notable aspects of the present approach are the use of readily available, bench-stable allyl alcohols and molecular oxygen as the terminal oxidant, in the process dispensing the need for unstable and costly enones. Further, we explored the synthetic utility of β-amino ketones through an intramolecular α-arylation methodology and a one-pot domino annulation, thereby providing rapid access to indolines and quinolines.
- Kumar, Gangam Srikanth,Singh, Diksha,Kumar, Manish,Kapur, Manmohan
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p. 3941 - 3951
(2018/04/14)
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- Palladium-catalyzed oxidative amination of homoallylic alcohols: Sequentially installing carbonyl and amino groups along an alkyl chain
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A novel Pd-catalyzed intermolecular cascade oxidative amination of homoallylic alcohols to yield β-amino ketones has been developed by using TBHP as the terminal oxidant. The synthetic utility of the reaction can be performed by installing the carbonyl an
- Ouyang, Lu,Huang, Jiuzhong,Li, Jianxiao,Qi, Chaorong,Wu, Wanqing,Jiang, Huanfeng
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supporting information
p. 10422 - 10425
(2017/09/25)
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- Cobalt-Porphyrin-Catalyzed Intramolecular Buchner Reaction and Arene Cyclopropanation of In Situ Generated Alkyl Diazomethanes
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Cobalt(II)-porphyrin catalyzed intramolecular Buchner reaction and arene cyclopropanation of alkyl diazomethanes generated in situ from N-tosylhydrazones gave a range of bicyclic cycloheptatriene fused pyrrolidines and tetracyclic cyclopropane fused pyrro
- Wang, Haixu,Zhou, Cong-Ying,Che, Chi-Ming
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supporting information
p. 2253 - 2258
(2017/07/07)
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- Heterobimetallic Pd-Sn catalysis: Michael addition reaction with C-, N-, O-, and S-nucleophiles and in situ diagnostics
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An efficient Michael addition reaction of differently substituted enones with carbon, sulfur, oxygen, and nitrogen nucleophiles has been achieved by a new heterobimetallic "Pd-Sn" catalyst system. The nature of the catalytically relevant species and their
- Das, Debjit,Pratihar, Sanjay,Roy, Sujit
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p. 2430 - 2442
(2013/04/23)
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- Zirconium tetrakis(dodecylsulfate) as an efficient and recyclable lewis acid-surfactant-combined catalyzed C-C and C-N bond forming under mild and environmentally benign conditions
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A green catalytic method for C-C and C-N bond forming via Michael addition of aromatic amines and indoles to electron-deficient olefins using Zirconium tetrakis(dodecylsulfate) in water under mild conditions with high yields and selectivity has been developed. The reusability of the catalyst has been successfully examined without any noticeable loss of its catalytic activity.
- Jafarpour, Maasoumeh,Rezaeifard, Abdolreza,Aliabadi, Marzieh
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scheme or table
p. 94 - 99
(2010/04/23)
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