- Method for synthesizing cis-difluoromethyl cyclohexane derivative and heterocyclic compound through hydrogenation
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The invention discloses a method for synthesizing a cis-difluoromethyl cyclohexane derivative and a heterocyclic compound through hydrogenation. According to the method, a cyclic (alkyl) (amino) carbene rhodium complex is used as a catalyst; a molecular s
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Paragraph 0021-0023; 0045-0047
(2020/01/25)
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- COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
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The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
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Page/Page column 569; 570
(2015/02/02)
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- Compounds and their use as BACE Inhibitors
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The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
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Page/Page column 44
(2012/07/13)
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