Exploring Rigid and Flexible Core Trivalent Sialosides for Influenza Virus Inhibition
Herein, the chemical synthesis and binding analysis of functionalizable rigid and flexible core trivalent sialosides bearing oligoethylene glycol (OEG) spacers interacting with spike proteins of influenza A virus (IAV) X31 is described. Although the flexible Tris-based trivalent sialosides achieved micromolar binding constants, a trivalent binder based on a rigid adamantane core dominated flexible tripodal compounds with micromolar binding and hemagglutination inhibition constants. Simulation studies indicated increased conformational penalties for long OEG spacers. Using a systematic approach with molecular modeling and simulations as well as biophysical analysis, these findings emphasize on the importance of the scaffold rigidity and the challenges associated with the spacer length optimization.
Preparation of aminoethyl glycosides for glycoconjugation
The synthesis of a number of aminoethyl glycosides of cell-surface carbohydrates, which are important intermediates for glycoarray synthesis, is described. A set of protocols was developed which provide these intermediates, in a short number of steps, from commercially available starting materials.
Sardzik, Robert,Noble, Gavin T.,Weissenborn, Martin J.,Martin, Andrew,Webb, Simon J.,Flitsch, Sabine L.
supporting information; experimental part
p. 699 - 703
(2011/01/03)
A new approach to the synthesis of 5-N-acetyl-D-neuraminic acid α-ketosides
-
Eschenfelder, Volker,Brossmer, Reinhard
p. 190 - 194
(2007/10/02)
More Articles about upstream products of 138478-06-5
Get Best Price for138478-06-5methyl-5-acetamido-2-O-(2'-benzyloxycarbonylaminoethyl)-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosonate