- Synthesis of lamellarin alkaloids using orthoester-masked α-keto acids
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Pyruvic acid and other α-keto acids are frequently encountered as intermediates in metabolic pathways, yet their application in total synthesis has met with limited success. In this work, we present a bioinspired strategy that utilizes highly functionaliz
- Shirley, Harry J.,Koyioni, Maria,Muncan, Filip,Donohoe, Timothy J.
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p. 4334 - 4338
(2019/04/17)
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- PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS
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The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the composition
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Paragraph 00297
(2013/07/31)
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- Short synthesis and antimalarial activity of fagaronine
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Herein, we report a new synthesis of fagaronine 1, inspired by the synthesis reported by Luo for nornitidine. The in vitro biological activity of fagaronine against malaria on several chloroquine-sensitive and resistant Plasmodium falciparum strains was c
- Rivaud,Mendoza,Sauvain,Valentin,Jullian
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experimental part
p. 4856 - 4861
(2012/08/29)
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- Total synthesis of lamellarins D, L, and N
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Total synthesis of cytotoxic marine alkaloids, lamellarins D, L, and N, has been achieved by using Hinsberg-type pyrrole synthesis and palladium-catalyzed Suzuki-Miyaura coupling of the 3,4-dihydroxypyrrole bistriflate 6 as the key reactions. The total yields of lamellarins D, L, and N from the common intermediate 6 are 54, 58, and 50%, respectively.
- Fujikawa, Naotaka,Ohta, Takeshi,Yamaguchi, Tomohiro,Fukuda, Tsutomu,Ishibashi, Fumito,Iwao, Masatomo
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p. 594 - 604
(2007/10/03)
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- Synthesis of Larreantin, a Cytotoxic Napththoquinoid Sesquilignan from Larrea tridentata
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Larreantin 1, a biogenetically unique cytotoxic naphthoquinoid sesquilignan has been synthesized by a convergent route.The key intermediate was 4,5-dihy
- Comber, Mark F.,Sargent, Melvyn V.
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p. 2783 - 2787
(2007/10/02)
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