Process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues
The invention relates to a process for the conversion of echinocandin class of peptides to their C4-homotyrosine monodeoxy analogues, particularly mulundocandin to deoxymulundocandin, which consists of a single step selective reduction of C4-htyr (homotyr
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Page/Page column 7-8
(2008/06/13)
Approaches towards the stabilization of hemiaminal function at ornithine unit of mulundocandin
Semisynthetic modifications at position-12 (ornithine-5-position, hemiaminal function) of mulundocandin were carried out to improve its chemical stability. New carbon-carbon (C-C) and carbon-hydrogen (C-H) linkage at hemiaminal function -12 has been achieved. Lewis acid catalyzed introduction of electron rich aryl group at position-12 of mulundocandin is developed. Synthesized mulundocandin analogues were evaluated for their chemical stability and antifungal activity against C. albicans and A. fumigatus.
Lal, Bansi,Gund, Vitthal Genbhau
p. 1123 - 1128
(2007/10/03)
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