138716-33-3

Basic information

• Product Name: 5-(2-Furyl)isoxazole, 95%
• Synonyms: 5-(2-Furyl)isoxazole, 95%;5-(furan-2-yl)-1,2-oxazole
• CAS NO: 138716-33-3
• Molecular Formula: C₇H₅NO₂
• Molecular Weight: 135.1201
• Mol File: 138716-33-3.mol

Chemical Properties

• Boiling Point: 41-43℃/0.23mm
• Appearance: /
• Refractive Index: 1.5560
• CAS DataBase Reference: 5-(2-Furyl)isoxazole, 95%(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Furyl)isoxazole, 95%(138716-33-3)
• EPA Substance Registry System: 5-(2-Furyl)isoxazole, 95%(138716-33-3)

Safety Data

• Hazardous Substances Data: 138716-33-3(Hazardous Substances Data)

Upstream product

• 109482-86-2 (2E)-3-(dimethylamino)-1-furan-2-ylprop-2-en-1-one 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 15578-13-9 1-(thiophen-2-yl)prop-2-yn-1-one 
• 17168-45-5 3-(dimethylamino)-1-(furan-2-yl)-2-propen-1-one 

Downstream Products

• 879373-65-6 [7-(3-amino-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-furan-2-yl-methanone 
• 931114-15-7 furan-2-yl-[7-(3-nitro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-methanone 
• 109920-25-4 N-[3-[3-(2-furanylcarbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-cyclopropanecarboxamide 

Relevant articles and documents

Harnessing Stereospecific Z-Enamides through Silver-Free Cp?Rh(III) Catalysis by Using Isoxazoles as Masked Electrophiles

The stereospecific synthesis of Z-enamides is described in this paper. For the first time, isoxazoles have been employed as electrophiles in C-H functionalization to afford thermodynamically less stable Z-enamides utilizing salicylaldehydes in an atom- and step-economic fashion. The stereochemistry of enamides might originate from the relative disposition of atoms present in isoxazole and the intramolecular hydrogen bonding. The reaction showed excellent scope as several structurally and electronically diverse salicylaldehydes and isoxazoles reacted efficiently.

TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3

A novel and efficient TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN3via a radical mechanism process is described. This methodology provides an easy access to a variety of useful 5-substituted isoxazoles

Synthesis and antibacterial activity of novel 5-(heteroaryl)isoxazole derivatives

The synthesis, characterization and antibacterial activity of novel isoxazole derivatives were reported. 3-Di (alkylamino)acryloalkanones were prepared and used as synthons to get the target isoxazole derivatives via reaction with hydroxylamine hydrochloride or hydroxylamine-O-sulphonic acid.

Reaction of β-dimethylaminovinyl ketones with hydroxylamine: A simple and useful method for synthesis of 3- and 5-substituted isoxazoles

(Chemical Equation Presented) The regioselective synthesis of 3- and 5-substituted-isoxazoles from the reaction of β-dimethylaminovinyl ketones [R-C(O)CH=CH-NMe2, where R = Ph, MeO-4-C6H4, F-4-C6H4, C

Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure-activity relationships

A novel series of antiproliferative agents containing pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides, selective for p21-deficient cells, were identified by high-throughput screening. Exploration of the SAR relationships in the headpiece, core, and tailpiece