Welcome to LookChem.com Sign In|Join Free

CAS

  • or

138887-02-2

2-Bromonaphthalene-1-carbonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

138887-02-2 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 138887-02-2 Structure

  • Basic information

    1. Product Name: 2-Bromonaphthalene-1-carbonitrile
    2. Synonyms: 2-Bromonaphthalene-1-carbonitrile
    3. CAS NO:138887-02-2
    4. Molecular Formula: C11H6BrN
    5. Molecular Weight: 232.07604
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 138887-02-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Bromonaphthalene-1-carbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Bromonaphthalene-1-carbonitrile(138887-02-2)
    11. EPA Substance Registry System: 2-Bromonaphthalene-1-carbonitrile(138887-02-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 138887-02-2(Hazardous Substances Data)

138887-02-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 138887-02-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,8,8 and 7 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 138887-02:
(8*1)+(7*3)+(6*8)+(5*8)+(4*8)+(3*7)+(2*0)+(1*2)=172
172 % 10 = 2
So 138887-02-2 is a valid CAS Registry Number.

138887-02-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromonaphthalene-1-carbonitrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138887-02-2 SDS

138887-02-2Downstream Products

138887-02-2Relevant articles and documents

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5?MTA Complex for the Treatment of MTAP-Deleted Cancers

Aranda, Ruth,Bobinski, Thomas P.,Briere, David M.,Burns, Aaron C.,Christensen, James G.,Clarine, Jeffery,Engstrom, Lars D.,Gunn, Robin J.,Ivetac, Anthony,Jean-Baptiste, Ronald,Ketcham, John M.,Kobayashi, Masakazu,Kuehler, Jon,Kulyk, Svitlana,Lawson, J. David,Marx, Matthew A.,Moya, Krystal,Olson, Peter,Rahbaek, Lisa,Smith, Christopher R.,Thomas, Nicole C.,Wang, Xiaolun,Waters, Laura M.

supporting information, p. 1749 - 1766 (2022/02/05)

The PRMT5?MTA complex has recently emerged as a new synthetically lethal drug target for the treatment of MTAP-deleted cancers. Here, we report the discovery of development candidate MRTX1719. MRTX1719 is a potent and selective binder to the PRMT5?MTA complex and selectively inhibits PRMT5 activity in MTAP-deleted cells compared to MTAP-wild-type cells. Daily oral administration of MRTX1719 to tumor xenograft-bearing mice demonstrated dose-dependent inhibition of PRMT5-dependent symmetric dimethylarginine protein modification in MTAP-deleted tumors that correlated with antitumor activity. A 4-(aminomethyl)phthalazin-1(2H)-one hit was identified through a fragment-based screen, followed by X-ray crystallography, to confirm binding to the PRMT5?MTA complex. Fragment growth supported by structural insights from X-ray crystallography coupled with optimization of pharmacokinetic properties aided the discovery of development candidate MRTX1719.

MTA-Cooperative PRMT5 Inhibitors

-

, (2021/03/19)

The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 138887-02-2