Oxygen alkylation of Schiff base derivatives of amino acids
Higher imine esters 1a-h and 7a-b of amino acids and dipeptides are prepared in 68-91% yield by saponification of the benzophenone Schiff base methyl esters 3a-d and 6 using phase-transfer techniques followed by O-alkylation with an alkyl halide. The procedure occurs with retention of configuration at the α-carbon except with phenylglycine derivatives.
O'Donnell,Cook,Rusterholz
p. 989 - 993
(2007/10/02)
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