Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
A novel class of fused pyrazole-derived inhibitors of p38α mitogen-activated protein kinase (MAPK) is disclosed. These inhibitors were evaluated for their ability to inhibit the p38α enzyme, the secretion of TNFα in a LPS-challenged THP1 cell line and TNF
Wurz, Ryan P.,Pettus, Liping H.,Xu, Shimin,Henkle, Bradley,Sherman, Lisa,Plant, Matthew,Miner, Kent,McBride, Helen,Wong, Lu Min,Saris, Christiaan J.M.,Lee, Matthew R.,Chmait, Samer,Mohr, Christopher,Hsieh, Faye,Tasker, Andrew S.
scheme or table
p. 4724 - 4728
(2010/05/17)
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