- An unprecedented Pd-catalyzed, water-promoted sequential oxidative aminocarbonylation-cyclocarbonylation process leading to 2-oxazolidinones
-
An unprecedented, Pdl2-catalyzed, sequential oxidative aminocarbonylation-cyclocarbonylation process, leading to 2-oxazolidinone derivatives 3 in good to excellent yields starting from readily available α,α-disubstituted 2-ynylamines 1 and secondary amines 2, is reported. In the case of an α-monosubstituted substrate, the initially formed 2-oxazolidinone derivative underwent shift of the double bond to give a 3H-oxazol-2-one derivative in excellent isolated yield.
- Gabriele, Bartolo,Plastina, Pierluigi,Salerno, Giuseppe,Mancuso, Raffaella,Costa, Mirco
-
p. 3319 - 3322
(2008/02/12)
-
- REACTIONS OF NITROGEN NUCLEOPHILES WITH 1-BROMOALLENES: REGIOSELECTIVE SYNTHESIS OF PROPARGYLAMINES
-
The results of a study on the reactivity of 3-alkyl- and 3,3-dialkyl-1-bromo-1,2-dienes 2 towards nitrogen nucleophiles, such as aqueous ammonia, lithium amide, aliphatic and aromatic amines allowed us to propose new methods for the synthesis of propargylamines, 1, with an available acetylenic hydrogen.The regio- and the stereoselectivity of these reactions are examined and possible mechanisms are discussed.
- Geri, Roberto,Polizzi, Carmela,Lardicci, Luciano,Caporusso, Anna Maria
-
p. 241 - 248
(2007/10/02)
-
- Copper Catalyzed Aminolysis of Bromoallenes as a New Efficient Route to Propargylamines
-
An efficient procedure of general applicability for the synthesis of secondary and tertiary propargylamines by copper mediated aminolysis of 1-bromo-1,2-dienes is described.Key Words: propargylamines; bromoallenes; aminolysis; regioselectivity; Cu promote
- Caporusso, Anna Maria,Geri, Roberto,Polizzi, Carmela,Lardicci, Luciano
-
p. 7471 - 7472
(2007/10/02)
-