Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines
A one-pot protocol toward several substituted 5,6-dihydrobenzo[4,5] imidazo[2,1-a]isoquinolines 1 starting with 2-allylbenzaldehydes 2 was described. The process was carried out the one-pot condensation/hydroamination reaction of substituted 2-allylbenzaldehydes 2 with 1,2-diaminobenzenes 3 in refluxing toluene in good yields. Skeleton 2 was prepared via one-pot ortho-metalative PhBCl2-mediated double alkylation of hydroxybenzaldehyde 4 with LDA in moderate yields.
Chang, Meng-Yang,Wu, Ming-Hao,Chen, Yeh-Long
supporting information; experimental part
p. 4156 - 4160
(2012/08/28)
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