139086-97-8

Basic information

• Product Name: N-(6-CHLORO-3-NITROPYRIDIN-2-YL)ACETAMIDE
• Synonyms: N-(6-CHLORO-3-NITROPYRIDIN-2-YL)ACETAMIDE;N-(6-Chloro-3-nitropyridin-2-yl)acetamide ,97%
• CAS NO: 139086-97-8
• Molecular Formula: C₇H₆ClN₃O₃
• Molecular Weight: 215.59384
• Mol File: 139086-97-8.mol

Chemical Properties

• Boiling Point: 432.1°C at 760 mmHg
• Flash Point: 215.1°C
• Appearance: /
• Density: 1.545g/cm³
• Vapor Pressure: 1.14E-07mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: N-(6-CHLORO-3-NITROPYRIDIN-2-YL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-CHLORO-3-NITROPYRIDIN-2-YL)ACETAMIDE(139086-97-8)
• EPA Substance Registry System: N-(6-CHLORO-3-NITROPYRIDIN-2-YL)ACETAMIDE(139086-97-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 139086-97-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H6ClN3O3/c1-4(12)9-7-5(11(13)14)2-3-6(8)10-7/h2-3H,1H3,(H,9,10,12)

Upstream product

• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 108-24-7 acetic anhydride 

Downstream Products

• 40851-92-1 5-chloro-2-methylimidazo<4,5-b>pyridine 
• 139086-99-0 2,3-diacetamido-6-chloropyridine 
• 40851-95-4 6-chloropyridine-2,3-diamine 

Relevant articles and documents

Inhibitors of glycogen synthase kinase 3

New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

SYNTHESIS OF SOME 1-ALKYL-1,4-DIHYDRO-4-OXO-1,7-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS

Reaction of substituted 2-aminopyridines IIIa, IIIb, IIIe, and IIIf with ethyl ethoxymethylene malonate provided corresponding pyridylaminomethylenemalonates Va-Vd, respectively.Thermal cyclization of Va, Vc, and Vd yielded substituted ethyl 4-hydroxy-1,7-naphthyridine-3-carboxylates VIa, VIc, and VId.Compounds VIc and VId treated with morpholine have 8-morpholino derivatives VIe and VIf.These compounds were ethylated to mixtures of N-ethylated (VIIa, VIIb) and O-ethylated products (VIIIa, VIIIb).Compound VIIIb was also prepared from ethyl 4-chloro-6-fluoro-8-morpholino-1,7-naphthyridine-3-carboxylate VIIIc and sodium ethanolate.Esters VIIa and VIIb were hydrolyzed under acidic conditions to the respective acids VIIc and VIId.