139101-19-2Relevant articles and documents
One-pot synthesis of 3,5-disubstituted and polysubstituted phenols from acyclic precursors
Qian, Jinlong,Yi, Wenbin,Huang, Xin,Miao, Yongbo,Zhang, Junkai,Cai, Chun,Zhang, Wei
supporting information, p. 1090 - 1093 (2015/03/14)
A new strategy for the synthesis of 3,5-disubstituted phenols is established through one-pot Robinson annulation of α,β-unsaturated ketones with α-fluoro-β-ketoesters followed by in situ dehydrofluorination and tautomerization. This method has been extended to the synthesis of polysubstituted phenols and applied in the preparation of biologically active compounds.
Titanium-catalyzed stereoselective geminal heterodihalogenation of β-ketoesters
Frantz, Richard,Hintermann, Lukas,Perseghini, Mauro,Broggini, Diego,Togni, Antonio
, p. 1709 - 1712 (2007/10/03)
(Matrix presented) β-Ketoesters can be effectively monofluorinated with F-TEDA using CpTiCl3 as a catalyst. With the use of this catalyst, the extent of the competing difluorination does not reach 10%. [TiCl2(TADDOLato)] complexes catalyze the one-pot enantioselective heterodihalogenation of β-ketoesters with F-TEDA and NCS to afford α-chloro-α-fluoro-β-ketoesters in moderate to good yields. The sequence of addition of the halogenating agents determines the sense of chiral induction.
