- Enantioselective chlorinative aldol reaction of α-substituted acroleins catalyzed by chiral phosphine oxides
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The enantioselective chlorinative aldol reaction of α-substituted acroleins with aldehydes catalyzed by chiral phosphine oxides is described. A hypervalent silicon complex-derived chloride adds to the α-substituted acroleins to form the corresponding sily
- Kotani, Shunsuke,Hanamure, Takuya,Nozaki, Hirono,Sugiura, Masaharu,Nakajima, Makoto
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supporting information
p. 282 - 287
(2017/02/18)
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- Facile synthesis of chiral 1,2-chlorohydrins via the ring-opening of meso-epoxides catalyzed by chiral phosphine oxides
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The facile synthesis of chiral 1,2-chlorohydrins via the enantioselective ring-opening of meso-epoxides with silicon tetrachloride in the presence of a chiral phosphine oxide was accomplished. The chiral 1,2-chlorohydrins were also obtained from the corresponding cis-alkenes in one-pot without significant loss in the selectivity, thereby permitting easy access to the 1,2-chlorohydrins from cis-alkenes with good yields and enantioselectivities.
- Kotani, Shunsuke,Furusho, Haruka,Sugiura, Masaharu,Nakajima, Makoto
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p. 3075 - 3081
(2013/03/28)
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- Process for producing optically active carboxylic acid
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A process for the production of an optically active carboxylic acid (I), which comprises subjecting an olefinic carboxylic acid (II) to asymmetric hydrogenation using a complex as a catalyst consisting of an optically active phosphine (III) and a ruthenium compound. Complex of STR1 with a ruthenium compound STR2 According to the process of the present invention, optically active carboxylic acids can be produced with high yield.
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- Synthesis of Partially Hydrogenated 2,2'-Bis(diphenylphosphenyl)-1,1'-binaphthyl (BINAP) Ligands and Their Application to Catalytic Asymmetric Hydrogenation
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Three pairs of new axially dissymmetric bisphosphane ligands, (R)-(-)- and (S)-(+)-2,2'-bis(dicyclohexylphosphanyl)-1,1'-binaphthyl , (R)-(+)- and (S)-(-)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl and (R)-(-)- and (S)-(+)-2,2'-bis(dicyclohexylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl , have been synthesized.The absolute configurations of the isomers 2 were determined by single-crystal X-ray diffraction of the linear 1:1 polymeric complex of (S)-(+)-2,2'-bis(dicyclohexylphosphinoyl)-1,1'-binaphthyl and (2R,3R)-(-)-di-O-benzoyltartaric acid , and those of the isomers 3 and 4 were established on the basis of CD spectra of the phosphanes and their bisoxides.X-Ray crystallographic studies of two cationic RhI complexes, (cod)>ClO4 and (cod)>ClO4 , revealed that complex (S)-17 possesses a dissymmetric structure, while complex (S)-18 has a pseudo-C2-symmetry and shows a significantly large dihedral angle between the two phenyl rings .The potentiality of ligand 3 for asymmetric catalysis was demonstrated in RuII-catalysed stereoselective hydrogenations of methyl 2-(benzamidomethyl)-3-oxobutanoate (21, in up to 92percent d.e. and 99percent e.e.) and geraniol (22, in 98percent optical purity).
- Zhang, Xiaoyong,Mashima, Kazushi,Koyano, Kinko,Sayo, Noboru,Kumobayashi, Hidenori,et al.
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p. 2309 - 2322
(2007/10/02)
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- 2,2'-bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl and transition metal complex containing the same as ligand
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2,2'-Bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl represented by formula (I). STR1 is disclosed. A transition metal complex containing the same, a process for producing 2,2'-Bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl, and a process for producing 2,2'-bis(diphenylphosphinyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl are also disclosed.
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- Synthesis of Partially Hydrogenated BINAP Variants
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Three pairs of new axially dissymmetric diphosphine ligands, (R)-(-)- and (S)-(+)-2,2'-bis(dicyclohexylphosphino)-1,1'-binaphthyl , (R)-(+)- and (S)-(-)-2,2'-bis(diphenylphosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphth
- Zhang, Xiaoyong,Mashima, Kazushi,Koyano, Kinko,Sayo, Noboru,Kumobayashi, Hidenori,et al.
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p. 7283 - 7286
(2007/10/02)
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