Synthesis of N?H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations
The synthesis of unsaturated, unprotected imidazolidinones via an aza-Heck reaction is described. This palladium-catalyzed process allows for the cyclization of N-phenoxy ureas onto pendant alkenes. The reaction has broad functional group tolerance, can b
Xu, Feiyang,Shuler, Scott A.,Watson, Donald A.
supporting information
p. 12081 - 12085
(2018/09/11)
Cardiotonic Agents. 7. Prodrug Derivatives Of 4-Ethyl-1,3-dihydro-5--2H-imidazol-2-one
The cardiotonic agent 4-ethyl-1,3-dihydro-5--2H-imidazol-2-one (1) was found to have low bioavailability when administered orally to rats and dogs.A series of N-acyl derivatives, an underutilized prodrug of acidic NH
Shaw, Kenneth J.,Erhardt, Paul W.,Hagedorn, Alfred A.,Pease, Cynthia A.,Ingebretsen, William R.,Wiggins, Jay R.
p. 1267 - 1272
(2007/10/02)
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