- Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives
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A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids is developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers.
- Bugera, Maksym,Trofymchuk, Serhii,Tarasenko, Karen,Zaporozhets, Olga,Pustovit, Yurii,Mykhailiuk, Pavel K.
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p. 16105 - 16115
(2019/12/24)
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- Reaction of cyclopropane carboxylic acid derivatives with sulphur tetrafluoride - An example of a diastereoselective ring opening
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Cyclopropane carboxylic acid derivatives can be converted into trifluoromethyl group-containing compounds using SF4. In the case of a bicyclic cyclopropane carboxylic acid lactone, similar treatment with sulphur tetrafluoride resulted in the cyclopropane ring opening in a diastereoselective manner.
- Hell,Finta,Dmowski,Faigl,Pustovit,Toke,Harmat
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p. 297 - 301
(2007/10/03)
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- Ortho-substituted benzyl esters of cyclopropanecarboxylic acids
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Ortho-substituted benzyl esters of cyclopropanecarboxylic acids I STR1 where X is N or CH and A is one of the following cyclopropane radicals: STR2 where R1 is CN, C2 -C8 -alkyl, CF3, C3 -C8 -alkenyl, (C1 -C4 -alkoxycarbonyl, unsubstituted or substituted phenyl-C1 -C6 -alkyl or phenyl-C3 -C6 -alkenyl, ethoxyphenyl, 2- or 3-bromophenyl, 2- or 4-trifluoromethylphenyl, 2,4- or 2,6-difluorophenyl, 2-fluoro-6-chlorophenyl, 2,4- or 2,6-dimethylphenyl, 2,3,6-trichlorophenyl or trimethylsilyl, R2 is H or halogen, R3 is unsubstituted or substituted phenyl, R4 is CH3 or halogen and Hal is halogen, with the proviso that X is CH when R1 is CF3 or trimethylsilyl, are suitable as fungicides and for controlling pests.
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