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139244-00-1

2-bromo-6-mercaptopurine, with the chemical formula C5H4BrN4S, is a derivative of the purine nucleoside adenine. It is a significant chemical compound that has garnered attention for its potential applications in medicine.
Used in Pharmaceutical Industry:
2-bromo-6-mercaptopurine is used as an anticancer agent for the treatment of leukemia and other cancers. It functions as a potent inhibitor of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT), which plays a crucial role in the synthesis of purine nucleotides. By inhibiting this enzyme, 2-bromo-6-mercaptopurine disrupts the cancer cells' ability to replicate DNA, thereby preventing their proliferation.
Additionally, 2-bromo-6-mercaptopurine is used as an immunosuppressive agent for the potential treatment of autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Its immunosuppressive properties make it a candidate for managing conditions where the immune system mistakenly attacks the body's own tissues.
However, the use of 2-bromo-6-mercaptopurine requires careful monitoring and management due to its potential to cause adverse effects, including myelosuppression, hepatotoxicity, and gastrointestinal disturbances. These side effects underscore the need for responsible clinical application and patient supervision.

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  • 139244-00-1 Structure

  • Basic information

    1. Product Name: 2-bromo-6-mercaptopurine
    2. Synonyms: 2-broMo-7H-purine-6-thiol
    3. CAS NO:139244-00-1
    4. Molecular Formula: C5H3BrN4S
    5. Molecular Weight: 231.07
    6. EINECS: N/A
    7. Product Categories: Purines
    8. Mol File: 139244-00-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-bromo-6-mercaptopurine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-bromo-6-mercaptopurine(139244-00-1)
    11. EPA Substance Registry System: 2-bromo-6-mercaptopurine(139244-00-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 139244-00-1(Hazardous Substances Data)

139244-00-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 139244-00-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,2,4 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 139244-00:
(8*1)+(7*3)+(6*9)+(5*2)+(4*4)+(3*4)+(2*0)+(1*0)=121
121 % 10 = 1
So 139244-00-1 is a valid CAS Registry Number.

139244-00-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-3,7-dihydropurine-6-thione

1.2 Other means of identification

Product number -
Other names 2-BROMO-6-MERCAPTOPURINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139244-00-1 SDS

139244-00-1Upstream product

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