- A general Pd-catalyzed decarboxylative cross-coupling reaction between aryl carboxylic acids: Synthesis of biaryl compounds
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Acid to acid: A general method has been developed for the synthesis of biaryl compounds through a decarboxylative cross-coupling reaction between two different (hetero)aryl carboxylic acids (see scheme). The use of a Pd II/PCy3 catalyst enables the cross-coupling reaction of electronically different or electronically similar aryl carboxylic acids. This method is compatible with substrates having nitro, cyano, fluoro, chloro, bromo, trifluoromethyl, and methoxy substituents. Copyright
- Hu, Peng,Shang, Yaping,Su, Weiping
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supporting information; experimental part
p. 5945 - 5949
(2012/07/03)
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