Selective RNA versus DNA G-quadruplex targeting by situ click chemistry
It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA. Copyright
Di Antonio, Marco,Biffi, Giulia,Mariani, Angelica,Raiber, Eun-Ang,Rodriguez, Rapha?l,Balasubramanian, Shankar
p. 11073 - 11078
(2013/01/15)
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