- Imidazonaphthyridine derivatives
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Disclosed are imidazonaphthyridine derivatives represented by formula (I) STR1 wherein: R1 represents lower alkyl or substituted or unsubstituted aryl; and X-Y-Z represents STR2 wherein R2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R5) H--(CH2)n --R4 (wherein R4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR6 R7 wherein R6 and R7 independently represents hydrogen or lower alkyl; R5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable sails thereof. The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.
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- New Antiinflammatory Agents. 2. 5-Phenyl-3H-imidazonaphthyridin-4(5H)-ones: A New Class of Nonsteroidal Antiinflammatory Agents with Potent Activity Like Glucocorticoids
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We previously described new antiinflammatory agents, 4-hydroxy-2-oxo-1-phenyl-1H-1,8-naphthyridine-3-carboxamides 1.Further modification of the compounds bearing 1-phenyl-1,8-naphthyridin-2-one as a mother skeleton led to 5-phenylimidazonaphth
- Suzuki, Fumio,Kuroda, Takeshi,Tamura, Tadafumi,Sato, Soichiro,Ohmori, Kenji,Ichikawa, Shunji
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p. 2863 - 2870
(2007/10/02)
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- A Facile and Novel Synthesis of 5-Phenylimidazonaphthyridin-4(5H)-ones
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A convenient and regioselective synthesis of a new heterocycle, 5-phenyl-1H or 3H-imidazonaphthyridin-4(5H)-one 1-a or 1-b, is described.Methyl 2-anilinonicotinate 15 was transformed into the valuable intermediate, N-phenyl-3-azaisatoic anhydr
- Kuroda, Takeshi,Suzuki, Fumio
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p. 2029 - 2034
(2007/10/02)
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