- Synthesis of prostaglandin analogues, latanoprost and bimatoprost, using organocatalysis via a key bicyclic enal intermediate
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Two antiglaucoma drugs, bimatoprost and latanoprost, which are analogues of the prostaglandin, PGF2?±, have been synthesized in just 7 and 8 steps, respectively. The syntheses employ an organocatalytic aldol reaction that converts succinaldehyde into a key bicyclic enal intermediate, which is primed for attachment of the required lower and upper side chains. By utilizing the crystalline lactone, the drug molecules were prepared in >99% ee.
- Pr??vost, S??bastien,Thai, Karen,Sch??tzenmeister, Nina,Coulthard, Graeme,Erb, William,Aggarwal, Varinder K.
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p. 504 - 507
(2015/03/05)
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- ESTER DERIVATIVES OF BIMATOPROST COMPOSITIONS AND METHODS
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Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same.
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Page/Page column 56-57
(2012/09/10)
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