139482-52-3

Basic information

• Product Name: 3-(3-hydroxypropyl)-5-phenyl-3,5-dihydro-4H-imidazo[4,5-c][1,8]naphthyridin-4-one
• Synonyms: 4H-imidazo[4,5-c][1,8]naphthyridin-4-one, 3,5-dihydro-3-(3-hydroxypropyl)-5-phenyl-
• CAS NO: 139482-52-3
• Molecular Formula: C₁₈H₁₆N₄O₂
• Molecular Weight: 320.3452
• Mol File: 139482-52-3.mol

Chemical Properties

• Boiling Point: 657.7°C at 760 mmHg
• Flash Point: 351.5°C
• Density: 1.36g/cm³
• Vapor Pressure: 3.42E-18mmHg at 25°C
• Refractive Index: 1.706
• CAS DataBase Reference: 3-(3-hydroxypropyl)-5-phenyl-3,5-dihydro-4H-imidazo[4,5-c][1,8]naphthyridin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-hydroxypropyl)-5-phenyl-3,5-dihydro-4H-imidazo[4,5-c][1,8]naphthyridin-4-one(139482-52-3)
• EPA Substance Registry System: 3-(3-hydroxypropyl)-5-phenyl-3,5-dihydro-4H-imidazo[4,5-c][1,8]naphthyridin-4-one(139482-52-3)

Safety Data

• Hazardous Substances Data: 139482-52-3(Hazardous Substances Data)

Upstream product

• 139339-02-9 5-phenyl-1H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one 
• 627-18-9 1-bromo-3-propanol 

Relevant articles and documents

Imidazonaphthyridine derivatives

Disclosed are imidazonaphthyridine derivatives represented by formula (I) STR1 wherein: R1 represents lower alkyl or substituted or unsubstituted aryl; and X-Y-Z represents STR2 wherein R2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R5) H--(CH2)n --R4 (wherein R4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR6 R7 wherein R6 and R7 independently represents hydrogen or lower alkyl; R5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable sails thereof. The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.

New Antiinflammatory Agents. 2. 5-Phenyl-3H-imidazonaphthyridin-4(5H)-ones: A New Class of Nonsteroidal Antiinflammatory Agents with Potent Activity Like Glucocorticoids

We previously described new antiinflammatory agents, 4-hydroxy-2-oxo-1-phenyl-1H-1,8-naphthyridine-3-carboxamides 1.Further modification of the compounds bearing 1-phenyl-1,8-naphthyridin-2-one as a mother skeleton led to 5-phenylimidazonaphth