139591-04-1

Basic information

• Product Name: 1-(2-PROPYNYL)-2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOLE
• Synonyms: 1-(2-PROPYNYL)-2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOLE
• CAS NO: 139591-04-1
• Molecular Formula: C₁₁H₇F₃N₂
• Molecular Weight: 224.18
• Mol File: 139591-04-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-PROPYNYL)-2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-PROPYNYL)-2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOLE(139591-04-1)
• EPA Substance Registry System: 1-(2-PROPYNYL)-2-(TRIFLUOROMETHYL)-1H-1,3-BENZIMIDAZOLE(139591-04-1)

Safety Data

• Hazardous Substances Data: 139591-04-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Propynyl)-2-(trifluoromethyl)-1H-1,3-benzimidazole is used as a potential drug candidate for its diverse biological activities, including antimicrobial, antifungal, anticancer, and anti-inflammatory properties. The presence of the trifluoromethyl group allows for the modulation of the compound's properties, making it a valuable asset in the development of new medications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(2-Propynyl)-2-(trifluoromethyl)-1H-1,3-benzimidazole is utilized for its ability to modulate the physicochemical, pharmacokinetic, and pharmacodynamic properties of drugs. This feature makes it a promising compound for the design and synthesis of novel therapeutic agents.
Further research and studies are required to explore the full potential of 1-(2-Propynyl)-2-(trifluoromethyl)-1H-1,3-benzimidazole in various applications and industries.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 312-73-2 2-Trifluoromethylbenzimidazole 
• 106-96-7 propargyl bromide 

Relevant articles and documents

A [...] benzimidazole compound and use thereof

The invention discloses a benzimidazole compound containing oxadiazole and application of the compound. The benzimidazole compound containing the oxadiazole is 1-[3-R-isoxazole-5-methylene]-2-trifluoromethyl-1H-benzimidazole[d] expressed by a formula (1) which is as shown in the specification, wherein R refers to substituted phenyl or 2-(3-methylthiophene); the substituted phenyl comprises one or more substituent groups, and each substituent group is independently selected from halogens, C1-C4 alkyls, C1-C4 alkoxyl groups, trifluoromethyl and bis(C1-C2 alkyl) substituted amino groups. The 1-[3-R-isoxazole-5-methylene]-2-trifluoromethyl-1H-benzimidazole[d] can be applied to preparing antibacterial agents. The 1-[3-R-isoxazole-5-methylene]-2-trifluoromethyl-1H-benzimidazole[d] has an inhibition effect on a plurality of bacteria (bacillus subtilis, escherichia coli, staphylococcus aureus and aspergillus fumigatus; the synthesis process of the compound is simple and prone to industrialization.

A containing 1, 2, 3-triazole benzimidazole compound and use thereof

The invention discloses a benzimidazole compound containing 1,2,3-triazole and an application thereof. The benzimidazole compound containing 1,2,3-triazole is 1-((1-R-1H-1,2,3-triazole-4yl)methyl)-2-(trifluoromethyl)-1H-benzimidazole[d] shown as the formula (I), wherein R substituent is benzyl, o-chlorobenzyl, C1-C12 alkyl or -R1COOR2; R1 is selected from straight chain or branched chain C1-C4 alkylene; and R2 is selected from straight chain or branched chain C1-C4 alkyl. The benzimidazole compound containing 1,2,3-triazole can be used for preparing an antibacterial agent; 1-((1-R-1H-1,2,3-triazole-4yl)methyl)-2-(trifluoromethyl)-1H-benzimidazole[d] has an inhabitation effect on a plurality of thallus bacteria, namely bacillus subtilis, escherichia coli, staphylococcus aureus and aspergillus fumigatus; the synthetic process is simple; and the industrialization is liable to implement.

Organostannyl mediated synthesis of 1-alkyl- and 1-sulfonyl-2-trifluoromethylbenzimidazole derivatives

The synthesis and characteristics of a new series of 1-alkyl and 1-sulfonyl derivatives of 2-trifluoromethylbenzimidazole through an organostannyl intermediate is described.