- Production of phenylpiperazines
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PROBLEM TO BE SOLVED: To provide a method for selectively producing piperazines with high yield.SOLUTION: Vicinal diamines and vicinal diols are subject to dehydrative cylization reaction in the presence of a Raney metal catalyst and a dehydration agent.
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Paragraph 0066
(2017/06/24)
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- COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS
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The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.
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Page/Page column 118
(2015/03/28)
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- Antiviral indoleoxoacetyl piperazine derivatives
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This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
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- Acyl derivatives of oxazolorifamycins
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The invention relates to novel acyl derivatives of rifamycins of the formula STR1 and the salts thereof, in which the structural elements --A1 --A2 --, --A3 --A4 -- and --A5 --A6 -- each de
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