Welcome to LookChem.com Sign In|Join Free

CAS

  • or
4-BENZYL-1-(THIOPHENE-2-CARBONYL)THIOSEMICARBAZIDE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

139614-66-7

Post Buying Request

139614-66-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

139614-66-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 139614-66-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,6,1 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 139614-66:
(8*1)+(7*3)+(6*9)+(5*6)+(4*1)+(3*4)+(2*6)+(1*6)=147
147 % 10 = 7
So 139614-66-7 is a valid CAS Registry Number.

139614-66-7Relevant articles and documents

Experimental and Theoretical Investigations Regarding the Thione–Thiol Tautomerism in 4-Benzyl-5-(thiophene-2-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

Sarac,Orek,Koparir

, p. 100 - 107 (2021/03/09)

Abstract: The title compound was synthesized by ring-closure reaction of thiophene-2-carbohydrazide with benzyl isothiocyanate and characterized using spectroscopic methods (NMR and FT-IR). Quantum chemical calculations at the B3LYP/6-311++G(d,p) level we

Searching for novel scaffold of triazole non-nucleoside inhibitors of HIV-1 reverse transcriptase

Fr?czek, Tomasz,Paneth, Agata,Kamiński, Rafa?,Krakowiak, Agnieszka,Paneth, Piotr

, p. 481 - 489 (2016/03/26)

Azoles are a promising class of the new generation of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). From thousands of reported compounds, many possess the same basic structure of an aryl substituted azole ring linked by a thioglycolamide chain with another aromatic ring. In order to find novel extensions for this basic scaffold, we explored the 5-position substitution pattern of triazole NNRTIs using molecular docking followed by the synthesis of selected compounds. We found that heterocyclic substituents in the 5-position of the triazole ring are detrimental to the inhibitory activity of compounds with four-membered thioglycolamide linker and this substitution seems to be viable only for compounds with shorter two-membered linker. Promising compound, N-(4-carboxy-2-chlorophenyl)-2-((4-benzyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide, with potent inhibitory activity and acceptable aqueous solubility has been identified in this study that could serve as lead scaffold for the development of novel water-soluble salts of triazole NNRTIs.

Small molecule inhibitors of HIV RT Ribonuclease H

Grandi, Martin Di,Olson, Matthew,Prashad, Amar S.,Bebernitz, Geraldine,Luckay, Amara,Mullen, Stanley,Hu, Yongbo,Krishnamurthy, Girija,Pitts, Keith,O'Connell, John

scheme or table, p. 398 - 402 (2010/04/05)

Two classes of compounds, thiocarbamates 1 and triazoles 2, have been identified as HIV RT RNase H inhibitors using a novel FRET-based HTS assay. The potent analogs in each series exhibited selectivity and were active in cell-based assays. In addition, sa

Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase-Structure-activity relationships and crystallographic analysis

Kirschberg, Thorsten A.,Balakrishnan, Mini,Huang, Wei,Hluhanich, Rebecca,Kutty, Nilima,Liclican, Albert C.,McColl, Damian J.,Squires, Neil H.,Lansdon, Eric B.

, p. 1131 - 1134 (2008/12/21)

A series of 3,4,5-trisubstituted 1,2,4-4H triazole derivatives was synthesized and investigated for HIV-1 reverse transcriptase inhibition. An X-ray structure with HIV-1 RT secured the binding mode and allowed the key interactions with the enzyme to be identified.

Superior reactivity of thiosemicarbazides in the synthesis of 2-amino-1,3,4-oxadiazoles

Dolman, Sarah J.,Gosselin, Francis,O'Shea, Paul D.,Davies, Ian W.

, p. 9548 - 9551 (2007/10/03)

(Chemical Equation Presented) A facile and general protocol for the preparation of 2-amino-1,3,4-oxadiazoles is reported. This method relies on a tosyl chloride/pyridine-mediated cyclization of a thiosemicarbazide, which is readily prepared by acylation o

Triazole derivatives and method of using the same to treat HIV infections

-

Page/Page column 8-9, (2008/06/13)

The present invention is directed to compounds of formula (I): wherein R1, R2 and R3 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl and X1 and X

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 139614-66-7