- Role of the hydrophobic moiety of tumor promoters. Synthesis and activity of 2-alkylated benzolactams
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The size and position of a hydrophobic moiety on a benzolactam skeleton, which reproduces the active conformation and biological activity of teleocidins, play an important role in the appearance of the activity. Compounds with alkyl groups of various sizes and shapes at the 2-position of benzolactam were synthesized. Structure-activity results indicate that a hydrophobic substituent at the C-2 position plays a critical role in the appearance of biological activities, as in the case of substitution at C-9.
- Endo, Yasuyuki,Yokoyama, Akihiro
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- Synthesis of Long Chain Substituted cis- and trans-2-Trichloromethyldioxolanones.
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Reaction of chloral hydrate with α-hydroxy derivatives of palmitic (Ia), stearic (Ib) and behenic (Ic) acids gave the corresponding cis-2-trichloromethyldioxolanones (IIa,b,c) and trans-2-trichloromethyldioxolanones (IIIa,b,c), yields being ca. 50percent for each reaction product.The structures of the individual reaction products were established clearly by elemental analysis as well as by spectral studies.
- Mukarram, Mohammad,Ahmad, Ishtiaque,Ahmad, Mashood
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p. 1949 - 1962
(2007/10/02)
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