Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters
An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.
A gram-scale synthesis of multi-substituted arenes via palladium catalyzed C-H halogenation
(6-Amino-2-chloro-3-fluorophenyl)methanol is prepared through both traditional methods and palladium catalyzed iterative C-H halogenation reactions. In comparison to traditional approach, the C-H functionalization strategy demonstrated a few advantages in
Sun, Xiu-Yun,Sun, Yong-Hui,Rao, Yu
p. 667 - 669
(2014/06/09)
NOVEL 2,5-DISUBSTITUTED PYRIMIDINE DERIVATIVES
The invention relates to novel 2,5-disubstituted pyrimidine derivatives, which stimulate the soluble guanylate cyclase, method for production and use thereof for the production of medicaments, in particular medicaments for the treatment of central nervous system diseases.
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Page/Page column 57
(2010/02/06)
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