DNA CLEAVAGE REACTION OF ANTITUMOUR ANTIBIOTIC, KAPURIMYCIN A3, WITH DEOXYTETRANUCLEOTIDE D(CGCG)2
Kapurimycin A3 (kap A3, 1) , an antitumour antibiotic, alkylates N7 of guanine2 (G2) and G4 of d(C1G2C3G4)2 to produce their covalent adducts 2 (64percent) and 3 (7.0percent), respectively.Heating at 90 deg C for 5 min degraded both adducts to kap-3 - G adduct (5) with the concurrent release of their respective abasic-site containing oligomers 4 and 6.
Get Best Price for139924-17-7Phosphoric acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester (2R,3S)-2,3,5-trihydroxy-pentyl ester