- Copper(II)-catalyzed sequential C,N-difunctionalization of 1,4-naphthoquinone for the synthesis of benzo[f]indole-4,9-diones under base-free condition
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An efficient synthesis of benzo[f]indole-4,9-diones has been achieved by copper(II)-catalyzed naphthoquinone sequential C,N-difunctionalization reactions with β-enaminones. New C-C and C-N bonds are easily formed in the reaction course. Copper(II) salt plays a dual role as Lewis acid and oxidative catalyst, and O2 acts as the terminal oxidant. The advantage of this reaction is the high atom economy with broad substrate scope and excellent yields. The reaction can be scaled up to using at least grams of substrates.
- Sun, Jin-Wei,Wang, Xiang-Shan,Liu, Yun
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- Activity analysis and preliminary inducer screening of the chicken DAZL gene promoter
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This study was aimed at identifying the active control area of chicken DAZL gene core promoter, to screen optimum inducers of the DAZL gene, thus to enhance the differentiation of embryonic stem cells into spermatogonial stem cells. Fragments of chicken DAZL gene promoter were cloned into fluorescent reporter plasmids and transfected into DF-1 cells. Then Dual-Luciferase Reporter Assay System was used to identify the activity of the DAZL gene under different inducers. Our studies showed that the DAZL core promoter region for the Suqin yellow chicken was 383 to 39 bp. The dual-luciferase reporter showed that all-trans retinoic acid (ATRA), a retinoic acid receptor alpha agonist (tamibarotene/Am80), or estradiol (E2) could significantly enhance DAZL transcription. The in vitro inductive culture of chicken ESCs demonstrated that, with ATRA treatment, DAZL transcription peaked at 6 days and then decreased slowly; whereas, DAZL transcription was continuous and peaked at 10 days with Am80 treatment. E E2 treatment significantly increased DAZL expression after 8 days. All three treatments were associated with the appearance of male germ cell (MGC)-like cells on day 10. These results provide the optimum inducer screening of the DAZL gene and lay the foundation for further screening of compounds that can induce the differentiation of ESCs into MGCs in vitro.
- Zhang, Lei,Zhu, Rui,Zuo, Qisheng,Li, Dong,Lian, Chao,Tang, Beibei,Xiao, Tianrong,Zhang, Yani,Li, Bichun
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p. 6595 - 6605
(2015/04/14)
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- Gold-catalyzed cascade C-C and C-N bond formation: Synthesis of polysubstituted indolequinones and pyrroles
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The combination of Ph3PAuCl and AgOTf was proven to be an efficient catalyst for the cascade C-C and C-N bond formation reactions from enamines and bromoquinones or nitroolefins. This protocol affords a straightforward method for the synthesis of polysubstituted indolequinones and pyrroles in good yields.
- Abdukader, Ablimit,Xue, Qicai,Lin, Aijun,Zhang, Ming,Cheng, Yixiang,Zhu, Chengjian
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supporting information
p. 5898 - 5900
(2013/10/21)
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- Expedient, one-pot preparation of fused indoles via CAN-catalyzed three-component domino sequences and their transformation into polyheterocyclic compounds containing pyrrolo[1,2-a]azepine fragments
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The CAN-catalyzed three-component between reaction between primary amines, β-dicarbonyl compounds and naphthoquinones or 2-bromonaphthoquinones afforded, respectively, 5-hydroxybenzo[g]indoles and benzo[f]indole-4,9-diones, the former of which were transformed into tetracyclic azepino[1,2-a]benzo[g] indole systems through a γ-alkylation/ring-closing metathesis sequence. The Royal Society of Chemistry 2010.
- Suryavanshi, Padmakar A.,Sridharan, Vellaisamy,Menendez, J. Carlos
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experimental part
p. 3426 - 3436
(2010/08/21)
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- Regioselective Synthesis of the Kinamycin ABCD ring system
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The new bromoquinone-enamine annulation was successfully extended to acyclic enamino ketones resulting in a new synthesis of the ABC framework 7 of kinamycins and when applied to cyclic enamino ketones 8a-c the first synthesis of their ABCD ring system.Smooth aromatisation of compounds 4b,d to 9a,b respectively was effected with DDQ. - Key Words: regiospecific annulation, metal catalysed; kinamycin; tetrahydrobenzocarbazole
- O'Sullivan, Patrick J.,Moreno, Rafael,Murphy, William S.
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p. 535 - 538
(2007/10/02)
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