The present invention provides compounds, compositions thereof, and methods of using the same.
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(2018/06/30)
Investigation of the origins of regiochemical control in [4+2] cycloadditions of 2-pyrones and alkynylboronates
The [4+2] cycloaddition of 2-pyrones with substituted alkynylboronates has been studied. In general, the highest yielding cycloadditions were obtained in reactions that employed a trimethylsilyl-substituted alkynylboronate. The highest regioselectivities were obtained using the corresponding phenyl-substituted alkyne, which provided a single regioisomer irrespective of the 2-pyrone used. Mechanistic studies suggest that the high regioselectivity observed is due to stabilization of a zwitterionic transition state. Georg Thieme Verlag Stuttgart · New York.
Kirkham, James D.,Leach, Andrew G.,Row, Eleanor C.,Harrity, Joseph P. A.
experimental part
p. 1964 - 1973
(2012/08/07)
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