- Application of double click to prepare near-infrared absorbing dye for photo-thermal tuning of cholesteric liquid crystal
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Cholesteric liquid crystal (CLC) exhibits selective reflection, making it a great application in the field of light control. Here, a near-infrared light (NIR) was used to drive the self-organizing spiral superstructure of the cholesteric liquid crystal to
- Cao, Hui,Gao, Hong,He, Wanli,Li, Zhitao,Miao, Zongcheng,Wang, Dong,Yang, Zhou,Zhao, Yuzhen
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Read Online
- C(sp3)-H Monoarylation of Methanol Enabled by a Bidentate Auxiliary
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With the assistance of a practical directing group (COAQ), the first catalytic protocol for the palladium-catalyzed C(sp3)-H monoarylation of methanol has been developed, offering an invaluable synthesis means to establish extensive derivatives of crucial arylmethanol functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional group compatibility, and even the practical synthesis of medicines further demonstrate the usefulness of this strategy.
- Gou, Quan,Ran, Man,Ren, Jian,Tan, Xiaoping,Yuan, Binfang,Yuan, Tengrui,Zhang, Ming-Zhong,Zhang, Xing
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supporting information
p. 118 - 123
(2021/01/13)
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- Enantioselective Construction of Si-Stereogenic Center via Rhodium-Catalyzed Intermolecular Hydrosilylation of Alkene
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Catalytic, enantioselective synthesis of stereogenic silicon compounds remains a challenge. Herein, we report a rhodium-catalyzed regio- and enantio-selective intermolecular hydrosilylation of alkene with prochiral dihydrosilane. This new method features a simple catalytic system, mild reaction conditions and a wide functional group tolerance.
- He, Tao,Liu, Li-Chuan,Ma, Wen-Peng,Li, Bin,Zhang, Qing-Wei,He, Wei
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supporting information
p. 17011 - 17015
(2020/11/30)
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- Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs
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(S)-Blebbistatin is a widely used research tool to study myosin II, an important regulator of many motility based diseases. Its potency is too low to be of clinical relevance, but identification of analogs with enhanced potency could deliver leads for tar
- Verhasselt, Sigrid,Roman, Bart I.,Bracke, Marc E.,Stevens, Christian V.
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- Synthesis and self-assembly of 5,5′-bis(phenylethynyl)-2,2′-bithiophene-based bolapolyphiles in triangular and square LC honeycombs
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A series of X-shaped 5,5′-bis(phenylethynyl)-2,2′-bithiophene-based bolaamphiphiles bearing two long lateral alkyl chains and two terminal glycerol groups has been synthesized by using Kumada and Sonogashira coupling reactions as key steps. The thermotropic liquid crystalline behavior of these compounds was investigated by POM, DSC and X-ray scattering. With elongation of the lateral alkyl chains two different kinds of liquid crystalline phases with honeycomb structures, ColhexΔ/p6mm, formed by (defective) triangular honeycomb cells, and Colsqu/p4mm with square cells were observed for these compounds. UV and PL measurements indicate fluorescent properties making them potential candidates for application in fluorescence sensor devices.
- Gao, Hongfei,Cheng, Huifang,Yang, Zonghan,Prehm, Marko,Cheng, Xiaohong,Tschierske, Carsten
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supporting information
p. 1301 - 1308
(2015/02/19)
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- Triblock polyphiles through click chemistry: Self-assembled thermotropic cubic phases formed by micellar and monolayer vesicular aggregates
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Three series of triblock polyphiles consisting of a rigid 4-phenyl-1,2,3-triazole or 1,4-diphenyl-1,2,3-triazole core with three lipophilic and flexible alkoxyl chains at one end and a polar glycerol group at the opposite end were synthesized by copper-ca
- Tan, Xiaoping,Kong, Leiyang,Dai, Heng,Cheng, Xiaohong,Liu, Feng,Tschierske, Carsten
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supporting information
p. 16303 - 16313
(2013/12/04)
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- A concise synthesis of 4′-O-methyl honokiol
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A concise and protecting group free synthesis of the naturally occurring neolignan 4′-O-methyl honokiol is developed. The key biaryl bond is constructed by 1,2-addition of an aryl Grignard reagent to a dienone followed by rearrangement.
- Denton, Ross M.,Scragg, James T.,Saska, Jan
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supporting information; experimental part
p. 2554 - 2556
(2011/06/21)
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- Synthesis of new cores and their use in the preparation of polyester dendrimers
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Six dendrimer and dendron cores terminated by hydroxyl groups that are neither phenolic nor cleavable by hydrogenolysis have been prepared in a consistent one-pot manner from terminal allyl groups by reduction of the product of reductive ozonolysis. Some of the terminal allyl derivatives are new and others have been prepared by new methods. The well-known O-benzylidene derivative of 2,2′-bis(hydroxymethyl)propanoic acid was shown to be the cis-stereoisomer. A new AB3-type anhydride, tris(benzyloxymethyl) acetic anhydride has been prepared. It was demonstrated that these cores and dendrons could be assembled into first and second generation homo- and mixed polyester dendrimers.
- Twibanire, Jean-D'Amour K.,Al-Mughaid, Hussein,Grindley, T. Bruce
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experimental part
p. 9602 - 9609
(2011/01/03)
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- NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY
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Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.
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Page/Page column 60; 62
(2010/10/20)
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- Thermodynamic, spectroscopic, and density functional theory studies of allyl aryl and prop-1-enyl aryl ethers. Part 1. Thermodynamic data of isomerization
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A chemical equilibration study of the relative thermodynamic stabilities of seventy isomeric allyl aryl ethers (a) and (Z)-prop-1-enyl aryl ethers (b) in DMSO solution has been carried out. From the variation of the equilibrium constant with temperature the Gibbs energies, enthalpies, and entropies of isomerization at 298.15 K have been evaluated. Because of their low enthalpies, the (Z)-prop-1-enyl aryl ethers are strongly favored at equilibrium, the Gibbs energies of the a→b isomerization ranging from -12 to -23 kJ mol-1. The entropy contribution is negligible in most reactions, but occasionally small positive values less than +10 J K-1 mol-1 of the entropy of isomerization are found. The equilibration studies were also extended to involve two pairs of related isomeric ethers with a Me substituent on C(2) of the olefinic bond. The Me substituent was found to increase the relative thermodynamic stability of the allylic ethers by ca. 3.4 kJ mol-1.
- Taskinen, Esko
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p. 1824 - 1834
(2007/10/03)
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- REACTIONS OF THIIRANES. X. REGIOSELECTIVITY OF RING-OPENING IN METHYL- AND VINYLTHIIRANES BY PHENOLS
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The effects of substituents in the phenol on the regioselectivity of the ring opening of methyl- and vinylthiiranes with phenols in the presence of 3-chloro-1-propene have been studied.Increasing the electron-donating properties of the substituent in the phenol increases the amount of the isomer corresponding to cleavage of the ring in accordance with Krasurskii's rule.The reaction rate was increased considerably when carried out in highly polar aprotic solvents.
- Tverdokhlebov, V. P.,Polyakova, N. Yu.,Tselinskii, I. V.
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p. 1258 - 1261
(2007/10/02)
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- REACTIONS OF THIIRANES. VII. MECHANISM OF THE OPENING OF THE THIIRANE RING BY R-PHENOLS IN THE PRESENCE OF 3-CHLORO-1-PROPENE WITH BASE CATALYSIS
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The kinetics of the opening of the thiirane ring by R-phenols in the presence of 3-chloro-1-propene under the conditions of base catalysis were studied.The effect of substituents in the aromatic ring on the rate constant for the formation of 4-thia-6-(R-phenoxy)-1-hexenes is described by a log k vs. ?- correlation.An isokinetic relationships is fulfilled in the investigated reaction series, and its features are discussed on the basis of the proposed reaction mechanism.
- Vergizova, T. V.,V'yunov, K. A.,Rodin, A. A.,Ginak, A. I.
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p. 2120 - 2125
(2007/10/02)
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