- BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS
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Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.
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Page/Page column 553
(2018/03/25)
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- AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS
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Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, [formula (I) should be inserted here]. Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods
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Page/Page column 91
(2016/11/17)
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- NITROGENATED HETEROCYCLIC COMPOUND
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The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of schizophrenia, Alzheimer's disease and the like. The present invention is a compound represented by the formula (1): wherein each symbol is as described in the specification, or a salt thereof.
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Paragraph 0650
(2015/03/28)
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- CRYSTAL FORMS OF AN IMIDAZOLE DERIVATIVE
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The invention relates to the essentially pure Λ/-[({2-[4-(2-Ethyl-4,6-dimethyl-1 H- imidazo[4,5-c]pyridin-1 -yl)phenyl]ethyl}amino)carbonyl]-4- methylbenzenesulfonamide Polymorph Forms A and B and to processes for the preparation of, compositions containi
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Page/Page column 28
(2008/06/13)
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- Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors
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A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a P3P2 dipeptide surrogate. The synthesis and antithrombotic activity of these inhibitors is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.
- Coburn, Craig A.,Rush, Diane M.,Williams, Peter D.,Homnick, Carl,Lyle, Elizabeth A.,Lewis, S. Dale,Lucas Jr., Bobby J.,Di Muzio-Mower, Jillian M.,Juliano, Marylou,Krueger, Julie A.,Vastag, Kari,Chen, I-Wu,Vacca, Joseph P.
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p. 1069 - 1072
(2007/10/03)
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- Synthesis of heterocyclic systems with carbohydrate fragment: 2. Stereoselective synthesis of tetrahydropyridones by reaction of levoglucosenone with amides of α-methylene-active acids
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The reactions of levoglucosenone with amides of several α-nitrocarboxylic acids and acetoacetic acid result in tetrahydropyridones fused with a carbohydrate fragment. In the case of acetoacetic acid amides, mixtures of keto and enol tautomers were obtained. The stereochemistry of cyclization is discussed in detail.
- Samet,Kislyi,Chernyshova,Reznikov,Ugrak,Semenov
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p. 393 - 398
(2007/10/03)
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