Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties
A series of tetracyclic nitrofuran isoxazoline anti-tuberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent anti-tuberculosis activity but suffered from poor solubility, high
Rakesh,Bruhn, David,Maddox, Marcus,Lee, Robin B.,Yang, Lei,Lee, Richard E.,Madhura, Dora B.,Trivedi, Ashit,Meibohm, Bernd,Scherman, Michael S.,Gilliland, Janet C.,Gruppo, Veronica,McNeil, Michael R.,Lenaerts, Anne J.
p. 6063 - 6072,10
(2020/08/20)
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