- Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation
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IRAK4 is a critical upstream kinase in the IL-1R/TLR signaling pathway. Inhibition of IRAK4 is hypothesized to be beneficial in the treatment of autoimmune related disorders. A screening campaign identified a pyrazole class of IRAK4 inhibitors that were d
- McElroy, William T.,Tan, Zheng,Ho, Ginny,Paliwal, Sunil,Li, Guoqing,Seganish, W. Michael,Tulshian, Deen,Tata, James,Fischmann, Thierry O.,Sondey, Christopher,Bian, Hong,Bober, Loretta,Jackson, James,Garlisi, Charles G.,Devito, Kristine,Fossetta, James,Lundell, Daniel,Niu, Xiaoda
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p. 677 - 682
(2015/06/30)
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- AMIDOPYRAZOLE INHIBITORS OF INTERLEUKIN RECEPTOR-ASSOCIATED KINASES
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This invention relates to amidopyrazole compounds that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment of cellular proliferative diseases, for example, cancer, hyperplasia, restenosis, cardiac hypertrophy, immune disorders and inflammation.
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Page/Page column 157; 158
(2012/10/08)
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