Reductive amination by continuous-flow hydrogenation: Direct and scalable synthesis of a benzylpiperazine
A benzylpiperazine was prepared directly from the corresponding benzaldehyde and piperazine on a continuous-flow hydrogenation apparatus. The synthesis was protecting group free, safe, and environmentally friendly. Large-scale synthesis under flow hydrogenation conditions was also demonstrated. Georg Thieme Verlag Stuttgart · New York.
Liu, Jing,Fitzgerald, Anne E.,Mani, Neelakandha S.