- Facile synthesis for benzo-1,4-oxazepine derivatives by tandem transformation of C-N coupling/C-H carbonylation
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A tandem transformation of C-N coupling/C-H carbonylation has been developed for the synthesis of benzo-1,4-oxazepine pharmaceutically derivatives. Notably, this reaction was accomplished by various phenylamine with ally halides under carbon dioxide atmosphere employing 2-(2-dimethylamino-vinyl)-1H-inden-1-olcatalyzed. Furthermore, under the optimized conditions, various benzo-1,4-oxazepine derivatives were obtained in good yields. Finally, a plausible CuI/CuIII mechanism of C-N coupling/C-H carbonylation transformation was proposed.
- Zhao, Xiaojia,Zhang, Jiong,Zheng, Zeqin,Xu, Runsheng
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- Click reaction of epoxides with anthranilic acids using neat grinding to access benzoxazepines
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An atom-economic, efficient, rapid (5 min), and highly regioselective one-pot click reaction has been developed for the synthesis of benzo[e][1,4]oxazepin-5-ones in excellent yields (78-92%). The method involves epoxide ring-opening-ring-closing cascade with anthranilic acids using neat grinding at room temperature in the presence of lithium bromide as a mild catalyst. In this procedure, pure products are obtained simply by washing the reaction mixture with warm water, thus hazardous solvents, tedious workup processes, and purification steps, such as column chromatography and recrystallization, are avoided. Georg Thieme Verlag Stuttgart · New York.
- Singh, Atul K.,Chawla, Ruchi,Yadav, Lal Dhar S.
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experimental part
p. 2353 - 2358
(2012/09/07)
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