Total synthesis of potent antitumor macrolide (-)-zampanolide: An oxidative intramolecular cyclization-based strategy
A detailed account of the enantioselective total synthesis of (-)-zampanolide, a macrolide marine natural product with high anticancer activity, is described. For the synthesis of the 4-methylenetetrahydropyran unit of (-)-zampanolide, we initially relied