- Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
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Two classes of ACK1 inhibitors, 4,5,6-trisubstituted furo[2,3-d]pyrimidin4- amines and 4,5,6-trisubstituted 7H-pyrrolo[2,3-d]pyrimidin-4-amines, were discovered and evaluated as ACK1 inhibitors. Further structural refinement led to the identification of potent and selective dithiolane inhibitor 37.
- Jiao, Xianyun,Kopecky, David J.,Liu, Jinsong,Liu, Jinqian,Jaen, Juan C.,Cardozo, Mario G.,Sharma, Rajiv,Walker, Nigel,Wesche, Holger,Li, Shyun,Farrelly, Ellyn,Xiao, Shou-Hua,Wang, Zhulun,Kayser, Frank
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p. 6212 - 6217
(2012/10/29)
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