- Synthesis of 11-Aminodibenzo[b,f][1,4]thiazepines and Fluoro Derivatives
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The reaction of halogenobenzonitriles with 2-aminobenzenethiol is a new route, in a "one-pot" or two-step approach, to 11-aminodibenzo[b,f][1,4]thiazepine and fluoro derivatives.
- Mettey, Yvette,Lehuede, Jacques,Vierfond, Jean-Michel
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Read Online
- Environmentally Friendly and Recyclable CuCl 2-Mediated C-S Bond Coupling Strategy Using DMEDA as Ligand, Base, and Solvent
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Simple reaction conditions and recyclable reagents are crucial for environmentally friendly industrial applications. An environment-friendly, recyclable and economic strategy was developed to synthesize diaryl chalcogenides by the CuCl2-catalyzed C S bondformation reaction via iodobenzenes and benzenethiols/1,2-diphenyldisulfanes using N,N'-dimethylethane-1,2-diamine (DMEDA) as ligand, base, and solvent. For these reactions, especially the reactions of diiodobenzenes and aminobenzenethiols/disulfanediyldianilines, a range of substrates are compatible and give the corresponding products in good to excellent yields. Both of the reagents in the catalytic system (CuCl2/DMEDA) are inexpensive, conveniently separable, and recyclable for more than five cycles.
- Shen, Guodong,Lu, Qichao,Wang, Zeyou,Sun, Weiwei,Zhang, Yalin,Huang, Xianqiang,Sun, Manman,Wang, Zhiming
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supporting information
p. 184 - 198
(2021/09/20)
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- Facile synthesis of 1,2-thiobenzonitriles: Via Cu-catalyzed denitrogenative radical coupling reaction
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A Cu-catalyzed synthesis of 1,2-thiobenzonitriles via oxidative C-N cleavage of 3-aminoindazoles followed by radical coupling with thiols is developed. A diverse array of 1,2-thiobenzonitriles were obtained in good yields with wide substrate scope. Notably, this is the first example of denitrogenative radical coupling with 3-aminoindazoles.
- Zhou, Yao,Wang, Ya,Lou, Yixian,Song, Qiuling
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supporting information
p. 10265 - 10268
(2019/09/03)
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- A PROCESS FOR THE PREPARATION OF QUETIAPINE
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The invention relates to a method for the preparation of 11- (4- [2- (2- hydroxyethoxy) ethyl] -1-piperazinyl] dibenzo [b, f ] -1, 4-thiazepine and pharmaceutically acceptable salts thereof comprising the reaction of 1- [2- (hydroxyethoxy) -ethyl] piperazine with dibenzo [b, f] [1, 4] thiazepin-11-ylamine.
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Page/Page column 9
(2009/09/05)
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- Antiviral dibenzothiazepinone derivatives
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Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same or different, each represent one or more ring substituent(s) selected from: hydrogen, hydroxy, halogen, cyano, nitro, C1-6 alkyl, C3-6 cycloalkyl or C1-6 alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); --NR4 R5 where R4 and R5, which may be the same or different, each represent hydrogen or C1-6 alkyl; --S(O)m R6, where m is 0, 1, 2 or 3 and R6 represents hydrogen, C1-6 alkyl or C3-6 cycloakyl; --SO2 NR4 R5 where R4 et R5 are each as defined above; phenyl, phenylC1-3 alkoxy or phenylC1-3 alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 alkoxy, hydroxy, nitro, halogen and amino; and --CO2 H or --COR7 where R7 is C1-6 alkyl or C3-6 cycloalkyl; R3 represents hydrogen or C1-4 alkyl; and esters, salts and other physiologically functional derivatives thereof; show activity as antiviral agents, for example against HIV. Certain of the compounds are novel.
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- Dibenzothiazepinthione as antiviral agents
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Compounds of formula (I) wherein n is 0, 1 or 2; and R1 and R2, which may be the same or different, each represent one or more ring substituent(s) selected from: hydroxy, halogen, cyano, nitro, C1-6 alkyl, C3-6 cycloalkyl or C1-6 alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); --NR4 R5 where R4 and R5 which may be the same or different, each represent hydrogen or C1-6 are each as defined above; phenyl, phenyl C1-3 alkoxy or phenyl C1-3 alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6 alkyl, C1-6 alkoxy, hydroxy, nitro, halogen and amino; and --CO2 H or --COR7 where R7 is C1-6 alkyl or C3-6 cycloalkyl; R3 is hydrogen or C1-4 alkyl: and esters, salts and other physiologically functional derivatives thereof, show activity as antiviral agents, for example against HIV. The majority of the compounds are novel.
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- TETRAZOLE DERIVATIVES AND DRUGS
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A compound of the formula [I] useful for treating allergic symptoms, cardiovascular disorders, cerebrovascular disorders, inflammation or other conditions mediated by SRS-A in humans and animals is disclosed. STR1
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- A NOVEL SYNTHETIC ROUTE TO CYANOPHENOTHIAZINES. FIRST EXAMPLE OF SMILES REARRANGEMENT FROM HALOGENOBENZONITRILES
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The reaction of halogenobenzonitriles with 2-aminobenzenethiol gave, by a Smiles rearrangement 2-mercaptocyanodiphenylamines which are cyclised to cyanophenothiazines via a disulfide intermediate.A mechanism is proposed.
- Mettey, Yvette,Vierfond, Jean-Michel
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p. 987 - 993
(2007/10/02)
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