Synthesis of 5'-phosphonate linked thymidine deoxyoligonucleotides
5'-Deoxy-5'-phosphonothymidine was synthesized and coupled with 3'-deoxy-3'-hydroxy-methylthymidine to yield a 3'-C-O-P-5' linked thymidine dinucleotide. This dimer as its 3'-phosphoramidite was used to synthesize deoxyoligonucleotides.
Kofoed, Thomas,Caruthers, Marvin H.
p. 6457 - 6460
(2007/10/03)
Oligonucleosides: Synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences
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Vasseur,Debart,Sanghvi,Cook
p. 4006 - 4007
(2007/10/02)
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