14068-13-4

Basic information

• Product Name: 2-Quinoxalineacetonitrile
• Synonyms: 2-Quinoxalineacetonitrile;(Quinoxalin-2-yl)acetonitrile;NSC 155196
• CAS NO: 14068-13-4
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.1827
• Mol File: 14068-13-4.mol

Chemical Properties

• Melting Point: 116-117℃
• Boiling Point: 327℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.242
• Vapor Pressure: 0.000209mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: 2-Quinoxalineacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Quinoxalineacetonitrile(14068-13-4)
• EPA Substance Registry System: 2-Quinoxalineacetonitrile(14068-13-4)

Safety Data

• Hazardous Substances Data: 14068-13-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Quinoxalineacetonitrile is utilized as a key intermediate in the synthesis of pharmaceutical compounds due to its ability to facilitate the development of new drug molecules with potential therapeutic applications.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-Quinoxalineacetonitrile is employed for the creation of diverse organic compounds, leveraging its unique structure and reactivity to produce a broad range of chemical entities.
Used in Material Science:
2-Quinoxalineacetonitrile has been investigated as a potential precursor for the synthesis of new materials and compounds, indicating its utility in various industrial fields beyond pharmaceuticals, including the development of advanced materials with specific properties.
Used in Antimicrobial Applications:
2-Quinoxalineacetonitrile has been studied for its potential biological activities, such as antibacterial and antifungal properties, suggesting its use in applications aimed at combating microbial infections.

InChI:InChI=1/C10H7N3/c11-6-5-8-7-12-9-3-1-2-4-10(9)13-8/h1-4,7H,5H2

Upstream product

• 108-24-7 acetic anhydride 
• 13311-43-8 β--α-hydroxyimino-propionsaeureethylester 
• 1448-87-9 2-chloroquinoxaline 

Downstream Products

• 944330-92-1 C₅₄H₅₄N₈O₂ 
• 1267681-17-3 C₁₀₀H₁₆₁N₅O₇ 

Relevant articles and documents

Bright and Stable NIR-II J-Aggregated AIE Dibodipy-Based Fluorescent Probe for Dynamic In Vivo Bioimaging

Organic dyes emitting in the second near-infrared (NIR-II, 900–1700 nm) window, with high molar extinction coefficients (MEC) and quantum yields (QY) in aqueous, are essential for in vivo bioimaging and biosensing. In this work, we developed a dibodipy-based aggregation-induced emission (AIE) fluorescent probe, THPP, to meet this aim. THPP exhibits a high MEC and has intensified absorption and emission in J-aggregated state, which significantly enhance the fluorescence intensity (≈55 folds) and extend the maximal absorption/emission wavelengths to 970/1010 nm in NIR-II region. Based on the bright THPP, imaging with a high frame rate (34 frames per second) at a deep “valid penetration depth” up to 6 mm can be achieved. This enabled simultaneous and dynamic imaging of vasculatures and deep tissues. Besides, we succeeded in monitoring the respiratory rate of acute-lung-injury mice and tracing the collateral circulation process with a high frame rate.

Pyrrolopyrrole cyanine dyes: A new class of near-Infrared dyes and fluorophores

Pyrrolopyrrole cyanine (PPCy) dyes are presented as a novel class of near-infrared (NIR) chromophores, which are synthesized in a condensation reaction of diketopyrrolopyr-role with heteroarylacetonitrile compounds. Their optical properties are marked by strong and narrow-band NIR absorptions. Complexation prod-ucts with BF2 and BPh2 show strong NIR fluorescence and hardly any ab-sorption in the visible range. We syn-thesized a series of new PPCys that differ only in the heterocyclic peripheral groups of the chromophore. With this strategy, the absorption spectra can be tuned between 684 and 864 nm, while high fluorescence quantum yields are maintained. The influence of the heterocycle on the optical properties of the dyes is discussed.